In TCGA clinical data on PTC patients (eBioPortal for Cancer Genomics https://www.cbioportal.org/) (Papillary thyroid carcinoma, Cell, 2014) [23], HOPX was positively correlated with CDH6 and LAMC2 that are involved in differentiation, while HOPX was negatively associated with HHEX and ERBB4 that contribute to dedifferentiation. This evidence concerns the gene ERBB4 and differentiated thyroid carcinoma.