SERPINF1 and ovarian cancer: PEDF protein level in serum is also slightly decreased in ovarian cancer patients compared to control patients (p ≤ 0.05, Figure 2B), whereas the level of PEDF in ascites is significantly higher compared to levels in serum from ovarian cancer patients (p ≤ 0.05; Figure 2B), suggesting that non-cancerous cells within the tumor environment secrete PEDF.