However, in the case of patients under the age of 35 with a detected unilateral adenoma of more than 10 mm and a structurally unaltered opposite adrenal gland, adrenal venous sampling is not mandatory if the aldosterone-to-renin ratio is higher than 30 ng/dl (831 pmol/l) and hypokalemia is evident [30]. The gene discussed is REN; the disease is Hypokalemia.