Although the co-expression of EGFR and EGFRvIII is rare in GBM cells,122 this co-expression is suggested to cooperate with tumour growth and induce macrophage infiltration.123 Also, the presence of EGFRvIII in exosomes correlated with a lower overall survivor pattern—21.1 months—compared with 28.6 months for patients with no EGFRvIII expression in exosomes.124. Here, EGFR is linked to glioblastoma.