6/8 had a higher score of EZH2 expression (Fig. 2A), 5/8 patients had a higher score of H3K27me3 (Fig. 2B), and conversely, only 2/8 COPD patients had a higher score of DAB2IP (Fig. 2C).Furthermore, in the area of metaplastic epithelium of COPD Smokers (n = 10) patients, 7/10 COPD smokers had a higher score of EZH2 expression (Fig. 2A), 7/10 patients had a higher score of H3K27me3 (Fig. 2B), and conversely, only 4/8 had a higher score of DAB2IP (Fig. 2C). The gene discussed is EZH2; the disease is chronic obstructive pulmonary disease.