In ECs and U87MG glioblastoma cells, however, it was demonstrated that stimulation with SEMA3B and SEMA6A only in presence of PLXNA2 induced localized disassembly of the actin cytoskeleton and focal adhesion points, followed by cell contraction and the appearance of thin projections that remain attached to the substrate around the contracted cell48, yielding a morphological resemblance with the co-cultured pericytes. The gene discussed is SEMA6A; the disease is glioblastoma.