CASP1 and inflammatory bowel disease: Based on the results of our RNA-seq analysis and the role of NLRP3 inflammasomes in inflammatory diseases, we used LPS to construct a model of IBD in rats and studied NLPR3 inflammasomes in this model, activated caspase 1 acts as a proinflammatory agent of cell death and is a key molecule in NLPR3 inflammasomes, which cause inflammation70,71.