To determine whether the ouabain-induced increase in locomotor activity, stereotypic behavior, and decrease in anxiety of mice is due to the activation of D2 dopamine receptors in the striatum after ICV ouabain injection, we performed a two-factor analysis of animal behavior under combined or separate administration of ouabain (50 μM, 0.5 μl bilaterally) and haloperidol (70 μg/kg intraperitoneally). This evidence concerns the gene DRD2 and Anxiety.