BSG and brain ischemia: In the present study, we did not specifically address the deleterious or beneficial effects of splenic monocytes in cerebral ischemia, but our findings reveal that (1) splenic monocytes are the major source of proinflammatory Ly-6Chigh MMs deployed to the ischemic brain, and (2) inhibition of CD147 significantly decreased the deployment and proinflammatory activation of spleen-derived Ly-6Chigh MMs to the ischemic brain after cerebral ischemia.