Wang et al. [32] has elegantly demonstrated that adoptive transfer of immune subsets 24 h before tMCAO including either non-activated or activated CD4+ or CD8+ T cells or activated monocytes to splenectomized male or female mice does not exacerbate infarct volume and neurological deficits 4 days after cerebral ischemia. The gene discussed is CD8A; the disease is Cerebral ischemia.