CCL2 and amyotrophic lateral sclerosis: In contrast, MCP1 expression was dramatically increased in both ALS cases with TDP-43 pathology (93 ± 7%, n = 72 cells, n = 4 patients, p < 0.0002; Fig. 8c, d) and ALS-FTLD cases with TDP-43 pathology (77 ± 4%, n = 44 cells, n = 3 patients, p < 0.002; Fig. 8e, f).