The anti-HMGB1-neutralizing antibody, administered i.p. at 1 mg/kg repeatedly on days 0, 1, 3, 4, 6, 7, 9, and 10 of oxaliplatin treatment, clearly prevented the development of oxaliplatin-induced hyperalgesia and allodynia (Fig. 1e), in agreement with the findings in the mouse model for oxaliplatin-induced peripheral neuropathy (see Fig. 1a). This evidence concerns the gene HMGB1 and peripheral neuropathy.