TNF and gestational diabetes: However, omentin-1, an adipokine expressed in non-fat cells from adipose tissue (i.e., stromal vascular cells) and involved in vascular tone relaxation by production of endothelial nitric oxide and reduction of both hs-CRP and TNFα signalling [130], was decreased at the 2nd trimester of GDM in parallel to adiponectin, and in contrast to IL-6 [119] (Table 3A).