In addition, BLOS2 is involved in several cellular processes independent of BLOC-1 and BORC [1], namely i) the inhibition of the transcriptional suppression activity of BRD7, which is a tumor suppressor candidate [3]; ii) negative regulation of Notch signaling, which is a highly conserved cell-to-cell signaling pathway [1]; and iii) the regulation of apoptotic cell death as the result of interacting with HIPPI (HIP-1 protein interactor) [1, 2]. This evidence concerns the gene BLOC1S2 and neoplasm.