Genetically predicted plasma levels of IL-6 receptor subunit alpha (sRa)/CRP/HDL and serum IgE, birth weight, body fat percentage, body mass index, diastolic and systolic blood pressure, fasting glucose and proinsulin levels, and waist circumference showed no evidence for association with risk of all glioma, GBM or non-GBM (Fig. 2–4). Here, IL6R is linked to central nervous system cancer.