Breast cancer cell studies showed that butein inhibits ER+ MCF-7 cells growth [21], and blocks CXCL12-induced migration and invasion of human epidermal growth factor receptor 2 positive (HER2+) in SKBR-3 breast cancer cells by repressing NFқB-dependent CXCR4 expression [22]. The gene discussed is ERBB2; the disease is breast cancer.