In the context of published studies demonstrating that FMRpolyG is the most abundantly translated RAN protein from CGG repeats and that production of FMRpolyG is required for inclusion formation in Drosophila, transfected cells and both CGG KI and CGG transgenic mice [22, 25, 26], these data are consistent with a disease model where FMRpolyG production is a central contributor to ubiquitinated neuronal intranuclear inclusion formation in FXTAS. Here, RAN is linked to fragile X-associated tremor/ataxia syndrome.