At the same time, in contrast to melanoma, high IGHG1/MS4A1 ratio, reflecting the relative abundance of IgG1-producing plasma cells compared to CD20+ (i.e., non-plasma) B-cells, is not associated with longer survival in KRASmut tumors, and tends to have a negative association for KRASwt tumors (data not shown). Here, IGHG1 is linked to melanoma.