In contrast, there is evidence for such a model in melanoma, based on the correlation of large hypermutating clonal IgG1 expansions [39] and high IGHG1/MS4A1 ratio with survival (p = 0.006, HR = 0.7), and cytotoxic activity of tumor-specific IgG1 antibodies [8]. The gene discussed is MS4A1; the disease is melanoma.