However, though Wnt/β-catenin signaling positively regulates EMT process, there may be a different role of RUVBL1 in EMT since high expression of cytoplasmic RUVBL1 was correlated with poor prognosis and metastatic progression of patients with carcinoma which cannot be explained by augmented Wnt/β-catenin signaling by nuclear RUVBL1 [66]. This evidence concerns the gene RUVBL1 and carcinoma.