However, the mechanism via which BMP3 activity is regulated and the role of its receptor-mediated signaling in tumorigenesis remain largely unknown, especially so in the development of CRC. In this paper, our goal is to determine what role, if any, BMP3 plays in CRC to understand why BMP3 inactivation seems to correlate with predisposition to carcinoma. The gene discussed is BMP3; the disease is colorectal carcinoma.