Next, the immunohistochemistry staining further revealed significantly higher protein levels of JMJD2C (encoded by KDM4C) in recurrent tumors and lung/liver metastasis than the ones in non-recurrent tumors (Fig. 1e), implying that JMJD2C overexpression correlated closely with CRC progression. Here, KDM4C is linked to colorectal carcinoma.