Histone demethylase JMJD2C has been reported to play crucial roles in the progression of colon cancer [19, 20], breast cancer [21–23], prostate cancer [24, 25], gastric cancer [26], lung cancer [27] and so on, indicating that JMJD2C represents a promising anti-cancer target. This evidence concerns the gene KDM4C and malignant colon neoplasm.