Based on bioinformatics analysis of the MALAT1 promoter, we found the potential binding sites for JMJD2C in the promoter of MALAT1, and hypothesized that, JMJD2C, the important histone demethylase, could influence the activity of MALAT1 promoter, thereby regulating MALAT1/β-catenin signaling pathway and leading to the promotion of CRC metastasis. The gene discussed is KDM4C; the disease is colorectal carcinoma.