By immunofluorescent staining assay, we found that, knockdown of JMJD2C could significantly decrease the nuclear accumulation of β-catenin protein in CRC cells, while overexpression of JMJD2C could effectively reverse the distribution of β-catenin in the nuclei of CRC cells (Fig. 5a, b). Here, KDM4C is linked to colorectal carcinoma.