SPRY2 and metabolic dysfunction-associated steatotic liver disease: However, it would be interesting to speculate that the changes in transcript levels of multiple genes associated with fatty acid synthesis and alterations to cholesterol synthesis pathways observed in the SPRY2 KO cells could constitute a potential mechanism leading to increased lipid droplet accumulation in hepatocytes, and potentially, a contribution by SPRY2 to conditions such as hepatic steatosis and NAFLD.