SPRY2 and obesity due to melanocortin 4 receptor deficiency: Collectively, the increase in glucose uptake and lipid droplet accumulation, as well as the modulation of transcript levels in SPRY2 KO cells suggest that SPRY2 may be involved in metabolic homeostasis in hepatocytes, although whether this contributes to the pathogenesis of obesity, T2DM or NAFLD remains to be determined using further in vitro experiments.