PLA2G2A (secretory phospholipase A2 group IIA) was the most significant upregulated gene (fold change 3.9; adjusted P = 1.43E− 20), which is of particular interest to metabolic diseases in the context of atherogenesis [31], hepatic cholesterol metabolism [32] and insulin sensitivity [33]. This evidence concerns the gene PLA2G2A and Other metabolic disease.