In the study of Bargagli and collaborators (2014), pro-thrombotic state of stable IPF patients (n = 10) and those experiencing acute exacerbation (n = 23) was associated with increased serum concentrations of D-dimers, factor VIII activity, fibrinogen, and homocysteine compared with controls (n = 44), while there was no difference between groups for CRP concentrations, protein C and protein S activities, and clotting times [16]. The gene discussed is PROS1; the disease is idiopathic pulmonary fibrosis.