IL6 and major depressive disorder: Proinflammatory cytokines such as IL-1 and IL-6 were found in both psoriasis and depression, indicating that the inflammatory process may be involved in the progression of both diseases.68 Depression in psoriasis patients was related to a high risk of stroke and cardiovascular death, especially during acute depression.69 The adaptation of vitiligo patients has been considered to be affected by self-esteem levels.