Exome sequencing of the right endometrioid carcinoma revealed a pathogenic mutation of hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase (H6PD), TFAP2D, MYO7A, TGM1, SEMA6B, ZNF99, and SIGLEC1. Loss of heterozygosity (LOH) in the 10q.23.3 (PTEN) locus was not recognized by copy number variation analysis in this tumor DNA. This evidence concerns the gene H6PD and neoplasm.