CD40LG and sexually transmitted disease: In addition, on univariable analysis, history of STIs (OR: 3.47, 95% CI: 1.36–8.91, p = 0.009) was significantly associated with specific HSV-2 IgM seropositivity and remained significant on multivariable logistic regression analysis (aOR: 3.70, 95% CI: 1.43–9.62, p = 0.007) (Table 3).