For example, previous studies showed that variants in HMGCR, encoding the target for statins, were associated with lower concentrations of LDL-C and lower risk of coronary heart disease [9] (CHD), while confirming the on-target nature of the effect of statins on higher body weight and higher risk of type 2 diabetes (T2DM) [9]. This evidence concerns the gene HMGCR and coronary artery disorder.