For example, one study concluded that TC/HDL-C underestimates the risk for AMI in comparison with apoB/apoA-I ratio [32] and results from the SCORE project concluded that TC/HDL-C is not superior to TC alone [21], even though others have concluded that TC/HDL-C is the most efficient IHD predictor [18, 19, 33]. This evidence concerns the gene APOA1 and myocardial ischemia.