The authors showed that silencing AS1DHRS4 resulted in both increased mRNA and protein expression of DHRS4, and increased mRNA expression of DHRS4L1 and DHRS4L2. The control exerted by this lncRNA on DHRS4L2 highlights the importance of this gene in the homeostasis and cell balance in AD. This evidence concerns the gene DHRS4 and Alzheimer disease.