We identified that variants harbored within the Solute Carrier Family 9 Member C1 (SLC9C1), the Casein Alpha S1 (CSN1S1), and the Lysyl Oxidase Like 4 (LOXL4) genes delay the AD age of onset (ADAOO) up to ~ 11 years. Here, LOXL4 is linked to Alzheimer disease.