ARHGDIA and neoplasm: Target genes were further shown to be enriched in platinum resistance-associated biological pathways, including axon guidance signaling related to tumorigenesis, Wnt/β-catenin signaling associated with cell proliferation and apoptosis, ATM signaling implicated in DNA damage and repair, SAPK/JNK signaling related to apoptosis, RhoGDI signaling implicated in tumor proliferation and metastasis and CDK5 signaling involved in cell cycle, etc (Fig. 4b).