In this study, through the differentiation of DPHCC and CK7- and CK19-negative HCC used the radiomics of Gd-EOB-DTPA-enhanced MRI, we think that the features of radiomics may achieve the preoperative prediction of the immunohistochemical markers of cholangiocellular carcinoma (CK7, CK19). This evidence concerns the gene KRT7 and cholangiocarcinoma.