In this study, through the differentiation of DPHCC and CK7- and CK19-negative HCC used the radiomics of Gd-EOB-DTPA-enhanced MRI, we think that the features of radiomics may achieve the preoperative prediction of the immunohistochemical markers of cholangiocellular carcinoma (CK7, CK19). The gene discussed is KRT19; the disease is cholangiocarcinoma.