Monoallelic variants in PLCG2 are associated with an autoinflammatory condition referred to as autoinflammation, antibody deficiency, and immune dysregulation syndrome (APLAID).6,21 Cosegregation analysis is ongoing in family members. The gene discussed is PLCG2; the disease is autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.