Beneficial effects on dystrophic skeletal muscle in mdx mice (ie, mice with an mdx allele mutation that is equivalent to the mutation in the human dystrophin gene, DMD, which causes DMD) have been observed.7,8 Mantuano et al8 suggested that despite the observed amelioration in muscle histopathology and ex vivo diaphragm force, no clear protective actions on dystrophic muscle metabolism in mdx mice were observed. Here, DMD is linked to Duchenne muscular dystrophy.