AKF-PD could also alleviate renal fibrosis by downregulating the expression of fibrogenic cytokines, such as transforming growth factor-β and connective tissue growth factor, and blocking the synthesis of Col I and Col III, promoting the degradation of ECM and inhibiting the oxidative stress and inflammatory response in vitro and in vivo (3). The gene discussed is CCN2; the disease is renal fibrosis.