IL1B and Hyperglycemia: After stimulation with LPS, the expression of IL-1β is increased in macrophages isolated from wounds of the T2D mouse model, with increased H3K4 methylation and decreased H3K27 methylation, suggesting that the expression of IL-1β is regulated by an epigenetic mechanism.132 It has recently been demonstrated that hyperglycemia leads to changes in the microRNA signature in wound healing, and they have been found to play a role in the dysregulated inflammation of diabetic wounds.