miR-155 plays a key role in macrophages, supporting and improving inflammation-induced atherosclerosis by directly repressing Bcl6.126 Moreover, it has been shown that miR-146a is involved in the pathogenesis of atherosclerosis, which negatively regulates macrophage maturation and inhibits inflammatory activation by reducing the expression of CD86 and CD80.127. The gene discussed is CD80; the disease is atherosclerosis.