Many molecules regulate the function and stability of Tregs, and of these, Lkb1 has recently been demonstrated to play an important role in maintaining the stability of Tregs based on conditional knockout mice models used in our previous study.19 The phenotype of the autoimmune disease of Foxp3CreLkb1f/f mice is very similar to that of aGVHD mice. This evidence concerns the gene STK11 and autoimmune disease.