SPRR2A and aortic aneurysm: However, increased levels of 15-LOX metabolites (i.e., 15-HETE, 15-HEPE, and 17-HDoHE) during aortic aneurysm development were only observed in TAAA, whereas increased levels of 12-LOX metabolites (i.e., 12-HETE, 12-HEPE, and 14-HDoHE) during aortic aneurysm development were only observed in AAAA.