Given the fact that the development of sperm motility and maturation is completed through progressive steps in epididymis6 and IL-6 could impact on cell differentiation through the SOCS3/STAT3 signaling pathway28, we postulate that elevated IL-6 may contribute to sperm malfunction and infertility of Ncoa5+/− male mice through impairing sperm motility and quality. The gene discussed is SOCS3; the disease is Infertility.