SERPINH1 and congenital rubella syndrome: Limitation of our study are (1) we classified by phenotypes instead of classifying by immunologic features such as the eosinophilic and non-eosinophilic CRS, (2) we did not checked whether inhibition of HSP47 cause aggravation of CRS in vivo, (3) siRNA has disadvantages, such as the variability and incompleteness of knockdowns.