IFI16 and systemic lupus erythematosus: In view of recent reports demonstrating that the cross-talk between cGAS and IFI16 regulates IFNβ expression in human keratinocytes36 and human macrophages37, it is conceivable that the strength of responses elicited by viral or synthetic DNA may differ from that triggered by nucleosomal dsDNA (nsDNA) detected in lupus patients19.