We saw that a synthetic LXR agonist, GW396533, increased ABCA1 RNA levels but did not change either NR1H2 or NR1H3 (the genes encoding LXRβ and LXRα) in either of two different glioma lines, TS543 and TS576 (Fig. 2D). The gene discussed is ABCA1; the disease is central nervous system cancer.