While both C57BL/6 (WT) and PSA-transgenic mice (C57BL/6 background) primary tumor-cured groups showed tumor growth retardation after rechallenge, only PSA-transgenic mice showed statistically significantly reduction in the tumor volume (p = 0.008, Dunn’s multiple comparisons) compared to the naïve group. This evidence concerns the gene KLK3 and neoplasm.