Parallel research in a large Dutch FAME pedigree (Family 3; Fig. 1c) linked to the same region on chr5p had revealed a missense variant (NM_001332.3:c.3130G>A, p.Glu1044Lys) in CTNND2, which segregated in all affected family members but one, who was considered a possible phenocopy13,14. Here, CTNND2 is linked to benign adult familial myoclonic epilepsy.