The pathogenic ATTTC insertion and expansion was always accompanied by the endogenous ATTTT pentanucleotide repeat in all cases of FAME2 that we describe here, replicating the findings in the cases of FAME with expansions in SAMD12, TNRC6A, RAPGEF210,11,19 and the report of a similar expansion in MARCH6 causing chr5-linked FAME20. The gene discussed is SAMD12; the disease is benign adult familial myoclonic epilepsy.