LRRK2 and Parkinson disease: Missense mutations within the GTPase domain (N1437H, R1441G/C, Y1699C) and kinase domains (G2019S, I2020T) hyper-activate LRRK2 protein kinase and cause Parkinson’s disease (PD) (Zimprich et al., 2004; Paisán-Ruíz et al., 2004; Alessi and Sammler, 2018).