A recent study demonstrated that overexpression of the CXCR4 ligand, SDF-1 in gastric cells can induce myofibroblast expansion and is consistent with the role of CXCR4 in pancreatic cancer (Quante et al., 2011; Shibata et al., 2013). This evidence concerns the gene CXCL12 and pancreatic neoplasm.