The build-up of these pathological features in the CLN4 fly model agrees with the assumed general concept of late onset neurodegenerative diseases, which typically show a progressive accumulation of protein aggregates and defects in protein homeostasis over a long period that is met by a declining age-dependent capacity of protein homeostasis (Labbadia and Morimoto, 2015). This evidence concerns the gene DNAJC5 and neurodegenerative disease.