Their important role in brain is underscored by studies showing genetic variation in the CACNA1C gene encoding Cav1.2, the major voltage-sensing and pore forming α1 subunit expressed in brain, is associated with neurodevelopmental, psychiatric and neurological disorders (Splawski et al., 2004; Ferreira et al., 2008; Bozarth et al., 2018). This evidence concerns the gene CACNA1C and nervous system disorder.