ADAMTS4 and melanoma: Of particular concerns are the coexistence of proteolytic fragments which contain only C‐terminal ancillary domains), the full‐length fragments, and NTAFs in the culture cells and tissues samples with melanoma.20 Our previous report26 and the present study shows that the dysregulation of ADAMTS4 by genetic factors such as mutant microRNA‐1268a increase the risk of HCC.