Next, we investigated the relationship between ADAMTS4 SNPs and OS of HCC cases and observed that ADAMTS4 rs538321148 and rs1014509103 polymorphisms and their haplotypes not only shortened OS time but also increased the death risk of patients with HCC [hazard ratio (95% CI), 2.04 (1.56‐2.66) for rs538321148‐TT, 2.81 (2.23‐3.54) for rs1014509103‐AA, and 5.64 (4.30‐7.39) for Haplotype with both rs538321148‐TT and rs1014509103‐AA respectively] (Figure 1). The gene discussed is ADAMTS4; the disease is hepatocellular carcinoma.