We found the expression of both Bax and cleaved Caspase 3, and Tunel positive rate were up‐regulated in H838 cells transfected with PGC‐1α siRNA (Group I v.s. Group III), and the level of the cell apoptosis didn't show obvious difference between the Control group and COX7A1 Overexpression group in PGC‐1α‐knockdown lung cancer cells (Group III vs. Group IV), which was consistent with the autophagy evaluation (Figure 2D,E). This evidence concerns the gene COX7A1 and lung carcinoma.