It is known to us that serum FLC assays in diagnostic screening panels were recommended currently by International Myeloma Working Group (IMWG).29 In addition, Thomas et al illustrated that serum free light chains should be used to evaluate response in light chain multiple myeloma.30 However, our study found the prognostic value of involved free light chain which was significantly related to reversibility from dialysis dependence. The gene discussed is TNFSF14; the disease is AL amyloidosis.